7 Jun ABSTRACT. Introduction: The skin acts as a barrier and prevents transcutaneous delivery of therapeutic agents. Transfersomes are novel. Key words: Edge activator, phosphatidylcholine, transfersomes, ultra-flexible Transfersome: A Novel Technique Which Improves Transdermal Permeability. 23 Feb prepare miconazole nitrate using Transfersomes to overcome the barrier Transfersomes was incorporated into a Carbapol gel base.
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Add to My Bibliography. Transdermal delivery of sertraline is a better-suited alternative to surmount the problems associated with its oral delivery. The carrier aggregate is composed of at least one amphiphat such as phosphatidylcholinewhich in aqueous solvents self-assembles into a lipid bilayer that closes into a simple lipid vesicle. The drug concentration in the resulting solution was assayed by a UV spectrophotometer Shimadzu-Japan at nm [ 9 ].
The polydispersity values of the formulation were found to be low 0. Cholesterol Chol was purchased from Carlo Erba Reagenti. Find articles by Samita Singla. The transfersomal gel formulations were evaluated for their rheological behavior using cone and plate configuration 40 mm cone with 2.
The pseudoplastic flow performance justifies that the developed system will require some force to expel. The total duration of immobility, struggling, and swimming were measured during a 5 min test. Received Aug 1; Accepted Aug Skin irritation studies were carried out according to the Ammar technique.
Photograph of the guinea pig a before applying any formulation b after applying drug solution c after applying drug gel d after applying transfersomes gel. Shed snake skin from the Siamese cobra Naja kaouthia was used as a model membrane for the skin permeation study because of its similarity to human skin in lipid content and permeability.
The formulation EL-SP4 and the transfersomal suspension showed the maximum tranfersomes amount of drug permeate 2. A Transfersome carrier is an artificial vesicle designed to exhibit the characteristics of a cell vesicle or a cell engaged in exocytosisand thus suitable for controlled and, potentially, targeted drug delivery.
Routes of administrationdosage forms. Preparation, characterization and performance evaluation.
The sample was filtered through 0. This result might be attributed to interactions between the surfactants NaO and NaChol and MX when the complex was inserted into the transfersomes bilayer.
This article is available from: The transfersomes were diluted with distilled water to give a total lipid concentration of 0. An increase in cholesterol could lead to increased stability and rigidity and decrease the permeability of the lipid bilayer, which may cause lower release of MX and lower permeation of MX through the skin [ 31 ].
Transfersomes for transdermal drug delivery. – PubMed – NCBI
The forced swim model test showed that the transfersomal gel formulation has better antidepressant activity because of the increased struggling behaviour of mice and the decreased time of immobility. This pseudoplasticity results from a colloidal network structure that aligns itself in the direction of shear, thereby decreasing the viscosity as the shear rate increases. Skin permeation studies The selected formulations on the basis of entrapment efficiency, drug content, and permeation through the cellophane membrane were subjected to permeation studies through rat skin using the Franz Diffusion cell in a similar manner as through the cellophane membrane.
This was due to better deformability of the transfersomal gel than of the drug gel. Each transfersomal gel formulation and control gel was subjected to in vitro drug release studies using a cellophane membrane.
On the other hand, the characteristic pressure needed to achieve a significant transport rate with the vesicles suspension mainly depends on the adaptability of the bilayer being evaluated. View at Google Scholar T. Four groups of guinea pigs with three animals each of either sex were used to study the hypersensitivity reaction on the skin.
The transfersomes were formulated by the conventional rotary evaporation sonication method [ 78 ]. Lecithin vesicular carriers for transdermal delivery of trahsfersomes A. This ratio was used to prepare the vesicles.
It also owed to better applicability due to the higher viscosity imparted by the gel rather than the transfersomal suspension, and no skin irritation transfdrsomes observed.
The mechanical properties and transportability of a vesicle can be studied by measuring stress- or deformation-dependent vesicle bilayer elasticity and changes in permeability.
Characterization and In Vitro Skin Permeation of Meloxicam-Loaded Liposomes versus Transfersomes
Analytical Technologies in the Biomedical and Life Sciencesvol. Abstract The goal of this study was tranafersomes develop and evaluate the potential use of liposome and transfersome vesicles in the transdermal drug delivery of meloxicam MX. At the same time, the surfactant also caused fluidization of the bilayer, which is also responsible for the increase in turbidity. The ex vivo permeation studies provide valuable information about the product behaviour in vivo since they indicate the amount of drug available for absorption.
The percentage of meloxicam transferwomes in vesicles composed of different compositions: For example, a Transfersome vesicle applied on an open biological surface, such as non-occluded skintends to penetrate its barrier and migrate into the water-rich deeper strata to secure adequate hydration.
Another attraction of Transfersome technology is the carrier’s ability to target transcersomes, subcutaneous tissue. The particle size of the transfersomes with different types of surfactant did not show a significant difference.
Transfersomes for transdermal drug delivery.
The viscosity of the transfersomal suspension was found to be low Transdermal drug delivery systems TDDs offer a number of potential advantages over conventional methods such as injectable and oral delivery [ 1 ]. The gel showed a flow index of 0.
Oxygen mask and Nasal cannula Oxygen concentrator Anaesthetic machine Relative analgesia machine. The enhancement ratio of the flux E pen was calculated as: De La Maza, J.
Development, characterization and performance evaluation. Generate a file for use with external citation management software. Formulation, in vitro evaluation, and stability studies.